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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.plaphy.2017.01.009
|2 doi
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|a (PII)S0981-9428(17)30017-7
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|e rakwb
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|a eng
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|a Nihei, Ken-Ichi
|e verfasserin
|4 aut
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|a Substituent effect of benzaldehydes on tyrosinase inhibition
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 01.05.2017
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Masson SAS. All rights reserved.
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|a Benzaldehyde inhibited the oxidation of 4-t-butylcatechol catalyzed by mushroom tyrosinase with an IC50 of 31.0 μM. The inhibition kinetics analyzed by Dixon plot indicated that it acts as a partial noncompetitive inhibitor. Further studies of several benzaldehydes, particularly those having a substitution at C-4, suggested that the partial inhibitory property diminished when using a bulk substituent. For example, 4-penthylbenzaldehyde showed a full and mixed type inhibition on diphenolase activity. Therefore, 4-substituted benzaldehyde on the aromatic ring primarily reflected the rate of product formation as it may act as a tight hydrophobic cover on the catalytic center of tyrosinase
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|a Journal Article
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|a Benzaldehydes
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|a Dixon plot
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|a Full inhibitor
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|a Partial inhibitor
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|a Tyrosinase
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|a Benzaldehydes
|2 NLM
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|a Enzyme Inhibitors
|2 NLM
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|a Monophenol Monooxygenase
|2 NLM
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|a EC 1.14.18.1
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|a Kubo, Isao
|e verfasserin
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|i Enthalten in
|t Plant physiology and biochemistry : PPB
|d 1991
|g 112(2017) vom: 06. März, Seite 278-282
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|x 1873-2690
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|g volume:112
|g year:2017
|g day:06
|g month:03
|g pages:278-282
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|u http://dx.doi.org/10.1016/j.plaphy.2017.01.009
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