Substituent effect of benzaldehydes on tyrosinase inhibition
Copyright © 2017 Elsevier Masson SAS. All rights reserved.
| Veröffentlicht in: | Plant physiology and biochemistry : PPB. - 1991. - 112(2017) vom: 06. März, Seite 278-282 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2017
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| Zugriff auf das übergeordnete Werk: | Plant physiology and biochemistry : PPB |
| Schlagworte: | Journal Article Benzaldehydes Dixon plot Full inhibitor Partial inhibitor Tyrosinase Enzyme Inhibitors Monophenol Monooxygenase EC 1.14.18.1 |
| Zusammenfassung: | Copyright © 2017 Elsevier Masson SAS. All rights reserved. Benzaldehyde inhibited the oxidation of 4-t-butylcatechol catalyzed by mushroom tyrosinase with an IC50 of 31.0 μM. The inhibition kinetics analyzed by Dixon plot indicated that it acts as a partial noncompetitive inhibitor. Further studies of several benzaldehydes, particularly those having a substitution at C-4, suggested that the partial inhibitory property diminished when using a bulk substituent. For example, 4-penthylbenzaldehyde showed a full and mixed type inhibition on diphenolase activity. Therefore, 4-substituted benzaldehyde on the aromatic ring primarily reflected the rate of product formation as it may act as a tight hydrophobic cover on the catalytic center of tyrosinase |
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| Beschreibung: | Date Completed 01.05.2017 Date Revised 30.09.2020 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1873-2690 |
| DOI: | 10.1016/j.plaphy.2017.01.009 |