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231224s2017 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2016.12.008
|2 doi
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|a pubmed24n0891.xml
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|a (DE-627)NLM267588119
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|a (NLM)28039016
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|a (PII)S1521-6616(16)30287-X
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhou, Jie
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a IL-17B is elevated in patients with pneumonia and mediates IL-8 production in bronchial epithelial cells
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 05.06.2017
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|a Date Revised 06.02.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a The role of IL-17B in regulating pulmonary immunity and inflammation is unknown. In this study, we found that IL-17B concentrations were significantly elevated in adult and paediatric patients with community-acquired pneumonia relative to their corresponding healthy adult and paediatric controls. The increased concentrations of IL-17B significantly and positively correlated with chemokine IL-8 concentrations in clinical pneumonia. In vitro studies demonstrated that IL-17B could induce gene and protein expression of IL-8 in human bronchial epithelial cells, but not lung fibroblasts, which was regulated by the activation of Akt, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and nuclear factor-kappaB (NF-κB) signaling pathways. In vivo studies further showed that increased IL-17B levels significantly and positively correlated with IL-8 concentrations in experimental pneumonia. In conclusion, human pneumonia was associated with enhanced release of IL-17B, which might regulate pulmonary immunity and inflammation through the induction of IL-8 in bronchial epithelial cells
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4 |
|a Journal Article
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|a Research Support, Non-U.S. Gov't
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4 |
|a Human lung tissue cells
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4 |
|a Il-17B
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4 |
|a Il-8
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4 |
|a Infection
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|a Pulmonary immunity
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| 650 |
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7 |
|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a Interleukin-8
|2 NLM
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| 650 |
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|a NF-kappa B
|2 NLM
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| 650 |
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7 |
|a Extracellular Signal-Regulated MAP Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.11.24
|2 NLM
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| 650 |
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7 |
|a p38 Mitogen-Activated Protein Kinases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.11.24
|2 NLM
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| 700 |
1 |
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|a Ren, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Dapeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Xue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Shifeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yin, Yibing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cao, Ju
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 175(2017) vom: 07. Feb., Seite 91-98
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:175
|g year:2017
|g day:07
|g month:02
|g pages:91-98
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2016.12.008
|3 Volltext
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