IL-17B is elevated in patients with pneumonia and mediates IL-8 production in bronchial epithelial cells

IL-17B is elevated in patients with pneumonia and mediates IL-8 production in bronchial epithelial cells

Copyright © 2016 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 175(2017) vom: 07. Feb., Seite 91-98
1. Verfasser: Zhou, Jie (VerfasserIn)
Weitere Verfasser: Ren, Lei, Chen, Dapeng, Lin, Xue, Huang, Shifeng, Yin, Yibing, Cao, Ju
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Human lung tissue cells Il-17B Il-8 Infection Pulmonary immunity Interleukin-17 Interleukin-8 NF-kappa B mehr... Extracellular Signal-Regulated MAP Kinases EC 2.7.11.24 p38 Mitogen-Activated Protein Kinases
Beschreibung
Zusammenfassung:Copyright © 2016 Elsevier Inc. All rights reserved.
The role of IL-17B in regulating pulmonary immunity and inflammation is unknown. In this study, we found that IL-17B concentrations were significantly elevated in adult and paediatric patients with community-acquired pneumonia relative to their corresponding healthy adult and paediatric controls. The increased concentrations of IL-17B significantly and positively correlated with chemokine IL-8 concentrations in clinical pneumonia. In vitro studies demonstrated that IL-17B could induce gene and protein expression of IL-8 in human bronchial epithelial cells, but not lung fibroblasts, which was regulated by the activation of Akt, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and nuclear factor-kappaB (NF-κB) signaling pathways. In vivo studies further showed that increased IL-17B levels significantly and positively correlated with IL-8 concentrations in experimental pneumonia. In conclusion, human pneumonia was associated with enhanced release of IL-17B, which might regulate pulmonary immunity and inflammation through the induction of IL-8 in bronchial epithelial cells
Beschreibung:Date Completed 05.06.2017
Date Revised 06.02.2018
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2016.12.008