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231224s2017 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/mrc.4570
|2 doi
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|a pubmed24n0891.xml
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Tsipis, Athanassios C
|e verfasserin
|4 aut
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|a 195 Pt NMR parameters as strong descriptors in one-parameter QSAR models for platinum-based antitumor compounds
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 26.04.2018
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|a Date Revised 26.04.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 John Wiley & Sons, Ltd.
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|a Highly predictive one-parameter quantitative structure-activity relationship models have been developed for platinum-based anticancer drugs using the 195 Pt NMR parameters as strong descriptors. The developed quantitative structure-activity relationship models were applied in diverse homogeneous sets of antiproliferative Pt(II) and Pt(IV) compounds. These observations form the basis for making predictions of cytotoxicity for a broad range of platinum-based antitumor compounds just from inspection of calculated or experimentally determined 195 Pt NMR parameters. Copyright © 2016 John Wiley & Sons, Ltd
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|a Journal Article
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|a 195Pt NMR
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|a 195Pt NMR descriptors
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|a Pt-based anticancer drugs
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|a QSAR model
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|a homogeneous series of Pt-based drugs
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| 650 |
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|a photoactivable Pt(IV) complexes
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| 650 |
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|a Antineoplastic Agents
|2 NLM
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| 650 |
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|a Coordination Complexes
|2 NLM
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| 650 |
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|a Solvents
|2 NLM
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| 650 |
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|a Platinum
|2 NLM
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| 650 |
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|a 49DFR088MY
|2 NLM
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| 700 |
1 |
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|a Karapetsas, Ioannis N
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 55(2017), 7 vom: 01. Juli, Seite 662-669
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
1 |
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|g volume:55
|g year:2017
|g number:7
|g day:01
|g month:07
|g pages:662-669
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|u http://dx.doi.org/10.1002/mrc.4570
|3 Volltext
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