195 Pt NMR parameters as strong descriptors in one-parameter QSAR models for platinum-based antitumor compounds
Copyright © 2016 John Wiley & Sons, Ltd.
| Veröffentlicht in: | Magnetic resonance in chemistry : MRC. - 1985. - 55(2017), 7 vom: 01. Juli, Seite 662-669 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2017
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| Zugriff auf das übergeordnete Werk: | Magnetic resonance in chemistry : MRC |
| Schlagworte: | Journal Article 195Pt NMR 195Pt NMR descriptors Pt-based anticancer drugs QSAR model homogeneous series of Pt-based drugs photoactivable Pt(IV) complexes Antineoplastic Agents Coordination Complexes Solvents mehr... |
| Zusammenfassung: | Copyright © 2016 John Wiley & Sons, Ltd. Highly predictive one-parameter quantitative structure-activity relationship models have been developed for platinum-based anticancer drugs using the 195 Pt NMR parameters as strong descriptors. The developed quantitative structure-activity relationship models were applied in diverse homogeneous sets of antiproliferative Pt(II) and Pt(IV) compounds. These observations form the basis for making predictions of cytotoxicity for a broad range of platinum-based antitumor compounds just from inspection of calculated or experimentally determined 195 Pt NMR parameters. Copyright © 2016 John Wiley & Sons, Ltd |
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| Beschreibung: | Date Completed 26.04.2018 Date Revised 26.04.2018 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.4570 |