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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.6b03764
|2 doi
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|a pubmed24n0890.xml
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|a (NLM)27959542
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wang, Huabin
|e verfasserin
|4 aut
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| 245 |
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|a Influence of Fimbriae on Bacterial Adhesion and Viscoelasticity and Correlations of the Two Properties with Biofilm Formation
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 02.08.2017
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|a Date Revised 02.08.2017
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a The surface polymers of bacteria determine the ability of bacteria to adhere to a substrate for colonization, which is an essential step for a variety of microbial processes, such as biofilm formation and biofouling. Capsular polysaccharides and fimbriae are two major components on a bacterial surface, which are critical for mediating cell-surface interactions. Adhesion and viscoelasticity of bacteria are two major physical properties related to bacteria-surface interactions. In this study, we employed atomic force microscopy (AFM) to interrogate how the adhesion work and the viscoelasticity of a bacterial pathogen, Klebsiella pneumoniae, influence biofilm formation. To do this, the wild-type, type 3 fimbriae-deficient, and type 3 fimbriae-overexpressed K. pneumoniae strains have been investigated in an aqueous environment. The results show that the measured adhesion work is positively correlated to biofilm formation; however, the viscoelasticity is not correlated to biofilm formation. This study indicates that AFM-based adhesion measurements of bacteria can be used to evaluate the function of bacterial surface polymers in biofilm formation and to predict the ability of bacterial biofilm formation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 700 |
1 |
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|a Wilksch, Jonathan J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Ligang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tan, Jason W H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Strugnell, Richard A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gee, Michelle L
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 33(2017), 1 vom: 10. Jan., Seite 100-106
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:33
|g year:2017
|g number:1
|g day:10
|g month:01
|g pages:100-106
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| 856 |
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|u http://dx.doi.org/10.1021/acs.langmuir.6b03764
|3 Volltext
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