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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.11.001
|2 doi
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|a pubmed24n0887.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Berker, Moritz
|e verfasserin
|4 aut
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| 245 |
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|a Allergies - A T cells perspective in the era beyond the TH1/TH2 paradigm
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|c 2017
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 13.06.2017
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|a Date Revised 18.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a Allergic diseases have emerged as a major health care burden, especially in the western hemisphere. They are defined by overshooting reactions of an aberrant immune system to harmless exogenous stimuli. The TH1/TH2 paradigm assumes that a dominance of TH2 cell activation and an inadequate TH1 cell response are responsible for the development of allergies. However, the characterization of additional T helper cell subpopulations such as TH9, TH17, TH22, THGM-CSF and their interplay with regulatory T cells suggest further layers of complexity. This review summarizes state-of-the-art knowledge on T cell diversity and their induction, while revisiting the TH1/TH2 paradigm. With respect to these numerous contributors, it offers a new perspective on the pathogenesis of asthma, allergic rhinitis (AR) and atopic dermatitis (AD) incorporating recent discoveries in the field of T cell plasticity
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|a Journal Article
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|a Review
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|a Research Support, Non-U.S. Gov't
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|a IL9 protein, human
|2 NLM
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|a Interleukin-9
|2 NLM
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|a Granulocyte-Macrophage Colony-Stimulating Factor
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|a 83869-56-1
|2 NLM
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| 700 |
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|a Frank, Larissa Johanna
|e verfasserin
|4 aut
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|a Geßner, Anja Lidwina
|e verfasserin
|4 aut
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|a Grassl, Niklas
|e verfasserin
|4 aut
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|a Holtermann, Anne Verena
|e verfasserin
|4 aut
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|a Höppner, Stefanie
|e verfasserin
|4 aut
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| 700 |
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|a Kraef, Christian
|e verfasserin
|4 aut
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| 700 |
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|a Leclaire, Martin Dominik
|e verfasserin
|4 aut
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| 700 |
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|a Maier, Pia
|e verfasserin
|4 aut
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| 700 |
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|a Messerer, David Alexander Christian
|e verfasserin
|4 aut
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| 700 |
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|a Möhrmann, Lino
|e verfasserin
|4 aut
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| 700 |
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|a Nieke, Jan Philipp
|e verfasserin
|4 aut
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| 700 |
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|a Schoch, Diana
|e verfasserin
|4 aut
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| 700 |
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|a Soll, Dominik
|e verfasserin
|4 aut
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|a Woopen, Christina Marianne Paulina
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 174(2017) vom: 01. Jan., Seite 73-83
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|g volume:174
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|u http://dx.doi.org/10.1016/j.clim.2016.11.001
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