Allergies - A T cells perspective in the era beyond the TH1/TH2 paradigm

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 174(2017) vom: 01. Jan., Seite 73-83
1. Verfasser:	Berker, Moritz (VerfasserIn)
Weitere Verfasser:	Frank, Larissa Johanna, Geßner, Anja Lidwina, Grassl, Niklas, Holtermann, Anne Verena, Höppner, Stefanie, Kraef, Christian, Leclaire, Martin Dominik, Maier, Pia, Messerer, David Alexander Christian, Möhrmann, Lino, Nieke, Jan Philipp, Schoch, Diana, Soll, Dominik, Woopen, Christina Marianne Paulina
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2017
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Review Research Support, Non-U.S. Gov't IL9 protein, human Interleukin-9 Granulocyte-Macrophage Colony-Stimulating Factor 83869-56-1

Beschreibung
Zusammenfassung:	Copyright © 2016 Elsevier Inc. All rights reserved. Allergic diseases have emerged as a major health care burden, especially in the western hemisphere. They are defined by overshooting reactions of an aberrant immune system to harmless exogenous stimuli. The TH1/TH2 paradigm assumes that a dominance of TH2 cell activation and an inadequate TH1 cell response are responsible for the development of allergies. However, the characterization of additional T helper cell subpopulations such as TH9, TH17, TH22, THGM-CSF and their interplay with regulatory T cells suggest further layers of complexity. This review summarizes state-of-the-art knowledge on T cell diversity and their induction, while revisiting the TH1/TH2 paradigm. With respect to these numerous contributors, it offers a new perspective on the pathogenesis of asthma, allergic rhinitis (AR) and atopic dermatitis (AD) incorporating recent discoveries in the field of T cell plasticity
Beschreibung:	Date Completed 13.06.2017 Date Revised 18.03.2022 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2016.11.001