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|a eng
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|a Cao, Lei-Fang
|e verfasserin
|4 aut
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|a Restoring Spinal Noradrenergic Inhibitory Tone Attenuates Pain Hypersensitivity in a Rat Model of Parkinson's Disease
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| 264 |
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|c 2016
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|a Text
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|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 26.10.2017
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|a Date Revised 21.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In the present study, we investigated whether restoring descending noradrenergic inhibitory tone can attenuate pain in a PD rat model, which was established by stereotaxic infusion of 6-hydroxydopamine (6-OHDA) into the bilateral striatum (CPu). PD rats developed thermal and mechanical hypersensitivity at the 4th week after surgery. HPLC analysis showed that NE content, but not dopamine or 5-HT, significantly decreased in lumbar spinal cord in PD rats. Additional noradrenergic depletion by injection of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) aggravated pain hypersensitivity in PD rats. At the 5th week after injection of 6-OHDA, systemic treatment with pharmacological norepinephrine (NE) precursor droxidopa (L-DOPS) or α2 adrenoceptor agonist clonidine significantly attenuated thermal and mechanical pain hypersensitivity in PD rats. Furthermore, application of norepinephrine (NE) and 5-hydroxytryptamine (5-HT) reuptake inhibitors duloxetine, but not 5-HT selective reuptake inhibitors sertraline, significantly inhibited thermal and mechanical pain hypersensitivity in PD rats. Systemic administration of Madopar (L-DOPA) or the D2/D3 agonist pramipexole slightly inhibited the thermal, but not mechanical, hypersensitivity in PD rats. Thus, our study revealed that impairment of descending noradrenergic system may play a key role in PD-associated pain and restoring spinal noradrenergic inhibitory tone may serve as a novel strategy to manage PD-associated pain
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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7 |
|a Benzylamines
|2 NLM
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7 |
|a Levodopa
|2 NLM
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| 650 |
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|a Oxidopamine
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|a Norepinephrine
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| 650 |
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7 |
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| 700 |
1 |
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|a Peng, Xiao-Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Ya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Bing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Feng-Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Ruo-Xiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Li-Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Wei-Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Tong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2016(2016) vom: 01., Seite 6383240
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|x 1687-5443
|7 nnas
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| 773 |
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|g volume:2016
|g year:2016
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