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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201603027
|2 doi
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|a pubmed24n0883.xml
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|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Li, Yi
|e verfasserin
|4 aut
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|a AuNP-Collagen Matrix with Localized Stiffness for Cardiac-Tissue Engineering
|b Enhancing the Assembly of Intercalated Discs by β1-Integrin-Mediated Signaling
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 09.10.2018
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|a Date Revised 04.12.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate β1-integrin signaling, which mediates the activation of integrin-linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF-2c
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|a Journal Article
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|a cardiac-tissue engineering
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|a gold nanoparticles
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|a intercalated discs
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|a localized stiffness
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|a β1-integrin
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|a GATA4 Transcription Factor
|2 NLM
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|a Gata4 protein, rat
|2 NLM
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|a Integrin beta1
|2 NLM
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|a MEF2 Transcription Factors
|2 NLM
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|a MEF2C protein, rat
|2 NLM
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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|a Collagen
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|a 9007-34-5
|2 NLM
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|a integrin-linked kinase
|2 NLM
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|a EC 2.7.1.-
|2 NLM
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|a Protein Serine-Threonine Kinases
|2 NLM
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|a EC 2.7.11.1
|2 NLM
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| 700 |
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|a Shi, Xiaoli
|e verfasserin
|4 aut
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|a Tian, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Hongyu
|e verfasserin
|4 aut
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|a Wu, Yujing
|e verfasserin
|4 aut
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|a Li, Xia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Jianjun
|e verfasserin
|4 aut
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|a Wei, Yujie
|e verfasserin
|4 aut
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|a Han, Xinxiao
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Jiao
|e verfasserin
|4 aut
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| 700 |
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|a Jia, Xiaowei
|e verfasserin
|4 aut
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| 700 |
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|a Bai, Rui
|e verfasserin
|4 aut
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| 700 |
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|a Jing, Limin
|e verfasserin
|4 aut
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| 700 |
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|a Ding, Peng
|e verfasserin
|4 aut
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|a Liu, Huiliang
|e verfasserin
|4 aut
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|a Han, Dong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 28(2016), 46 vom: 02. Dez., Seite 10230-10235
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|g volume:28
|g year:2016
|g number:46
|g day:02
|g month:12
|g pages:10230-10235
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|u http://dx.doi.org/10.1002/adma.201603027
|3 Volltext
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