AuNP-Collagen Matrix with Localized Stiffness for Cardiac-Tissue Engineering Enhancing the Assembly of Intercalated Discs by β1-Integrin-Mediated Signaling

AuNP-Collagen Matrix with Localized Stiffness for Cardiac-Tissue Engineering : Enhancing the Assembly of Intercalated Discs by β1-Integrin-Mediated Signaling

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 28(2016), 46 vom: 02. Dez., Seite 10230-10235
1. Verfasser: Li, Yi (VerfasserIn)
Weitere Verfasser: Shi, Xiaoli, Tian, Lei, Sun, Hongyu, Wu, Yujing, Li, Xia, Li, Jianjun, Wei, Yujie, Han, Xinxiao, Zhang, Jiao, Jia, Xiaowei, Bai, Rui, Jing, Limin, Ding, Peng, Liu, Huiliang, Han, Dong
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article cardiac-tissue engineering gold nanoparticles intercalated discs localized stiffness β1-integrin GATA4 Transcription Factor Gata4 protein, rat Integrin beta1 MEF2 Transcription Factors mehr... MEF2C protein, rat Gold 7440-57-5 Collagen 9007-34-5 integrin-linked kinase EC 2.7.1.- Protein Serine-Threonine Kinases EC 2.7.11.1
Beschreibung
Zusammenfassung:© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate β1-integrin signaling, which mediates the activation of integrin-linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF-2c
Beschreibung:Date Completed 09.10.2018
Date Revised 04.12.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201603027