From start to finish amino-terminal protein modifications as degradation signals in plants

From start to finish : amino-terminal protein modifications as degradation signals in plants

© 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 211(2016), 4 vom: 20. Sept., Seite 1188-94
1. Verfasser: Gibbs, Daniel J (VerfasserIn)
Weitere Verfasser: Bailey, Mark, Tedds, Hannah M, Holdsworth, Michael J
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Review Research Support, Non-U.S. Gov't N-degron N-end rule N-terminus Nt-acetylation protease protein modification proteolysis mehr... ubiquitin proteasome system Plant Proteins
Beschreibung
Zusammenfassung:© 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.
Contents 1188 I. 1188 II. 1189 III. 1190 IV. 1191 V. 1192 1192 References 1192 SUMMARY: The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- and posttranslational modifications. Many of these create degradation signals (N-degrons) that mediate protein destruction via the N-end rule pathway of ubiquitin-mediated proteolysis. In plants, the N-end rule pathway has emerged as a major system for regulated control of protein stability. Nt-arginylation-dependent degradation regulates multiple growth, development and stress responses, and recently identified functions of Nt-acetylation can also be linked to effects on the in vivo half-lives of Nt-acetylated proteins. There is also increasing evidence that N-termini could act as important protein stability determinants in plastids. Here we review recent advances in our understanding of the relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plants
Beschreibung:Date Completed 26.01.2018
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1469-8137
DOI:10.1111/nph.14105