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20231224201637.0 |
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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-016-1693-z
|2 doi
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|a pubmed24n0874.xml
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|a (DE-627)NLM262384051
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Bhalla, Renu
|e verfasserin
|4 aut
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| 245 |
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|a Toxicity of hydroxylated polychlorinated biphenyls (HO-PCBs) using the bioluminescent assay Microtox(®)
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 10.01.2017
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Hydroxylated polychlorinated biphenyls (HO-PCBs) are toxic contaminants which are produced in the environment by biological or abiotic oxidation of PCBs. The toxicity of a suite of 23 mono-hydroxylated derivatives of PCBs and 12 parent PCBs was determined using the bacterial bioluminescent assay Microtox(®). All HO-PCBs tested exhibited higher toxicity than the corresponding parent PCB, with effect concentration 50 % (EC50) ranging from 0.07 to 133 mg L(-1). The highest toxicities were recorded with 4-hydroxylated derivatives of di-chlorinated biphenyls (EC50 = 0.07-0.36 mg L(-1)) and 2-hydroxylated derivatives of tri-chlorinated biphenyls carrying a chlorine substituent on the phenolic ring (EC50 = 0.34-0.48 mg L(-1)). The toxicity of HO-PCBs generally decreased when the degree of chlorination increased. Consistently with this observation, a significant positive correlation was measured between toxicity (measured by EC50) and octanol-water partition coefficient (pK ow) for the HO-PCBs under study (Pearson's correlation coefficient, r = 0.74), which may be explained by the lower solubility and bioavailability generally associated with higher hydrophobicity. This study is the first one which assessed the toxicity of a suite of PCBs and HO-PCBs using the bioluminescent assay Microtox(®), showing an inverse correlation between toxicity and hydrophobicity
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|a Journal Article
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|a Bioluminescent assay
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|a Hydroxylated polychlorinated biphenyl–HO-PCB
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|a Microtox®
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|a Structure–activity relationship–SAR
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|a Toxicity
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|a Environmental Pollutants
|2 NLM
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|a Polychlorinated Biphenyls
|2 NLM
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| 650 |
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1 |
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|a Tehrani, Rouzbeh
|e verfasserin
|4 aut
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1 |
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|a Van Aken, Benoit
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 25(2016), 7 vom: 13. Sept., Seite 1438-44
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
1 |
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|g volume:25
|g year:2016
|g number:7
|g day:13
|g month:09
|g pages:1438-44
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|u http://dx.doi.org/10.1007/s10646-016-1693-z
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