Polymer Capsules for Plaque-Targeted In Vivo Delivery

Polymer Capsules for Plaque-Targeted In Vivo Delivery

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 28(2016), 35 vom: 30. Sept., Seite 7703-7
1. Verfasser: Richardson, Joseph J (VerfasserIn)
Weitere Verfasser: Choy, Mei Y, Guo, Junling, Liang, Kang, Alt, Karen, Ping, Yuan, Cui, Jiwei, Law, Lok S, Hagemeyer, Christoph E, Caruso, Frank
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article click-chemistry degradation nanomedicine polymer blends templating Capsules Polymers
Beschreibung
Zusammenfassung:© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for postfunctionalization with targeting peptides specific to plaques
Beschreibung:Date Completed 11.09.2018
Date Revised 30.09.2020
published: Print-Electronic
ErratumIn: Adv Mater. 2016 Sep;28(36):7820. - PMID 27717055
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201601754