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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.05.008
|2 doi
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|a pubmed24n0869.xml
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|a (DE-627)NLM260815411
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|a (NLM)27233983
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|a (PII)S1521-6616(16)30081-X
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Steckner, Corinna
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Alteration of the cytokine signature by various TLR ligands in different T cell populations in MOG37-50 and MOG35-55-induced EAE in C57BL/6 mice
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| 264 |
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1 |
|c 2016
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 30.03.2017
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| 500 |
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|a Date Revised 30.03.2017
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| 500 |
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a Interleukin 17 (IL-17), produced by T cells, plays an important role in Multiple Sclerosis (MS) and its animal model, Experimental Autoimmune Encephalomyelitis (EAE). In contrast to IL-17-producing CD4+ T cells, the contribution of IL-17-producing CD8+ T cells (Tc17) in CNS autoimmunity has been investigated less intensively. Here we investigate the role of TC17 in EAE. We compare different T cell populations and their cytokine pattern in the MOG35-55- and MOG37-50-induced EAE. We detected a similar cytokine phenotype for both EAE models in the autoimmune process assessed at different stages. Regarding the migratory activity, an involvement of IL-17 and IFN-γ in disease onset was suggested. Furthermore, we show that PAMPs have the ability to drive autoimmune process. To modify the cytokine pattern of different T cell populations, a combination of distinct factors is required (the activation of MyD88 or Syk, the genetic background, the presence of APCs and CD4+ T cells)
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a EAE
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| 650 |
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4 |
|a IL-17
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| 650 |
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4 |
|a MOG
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| 650 |
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4 |
|a T cell
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| 650 |
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4 |
|a TLR
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| 650 |
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7 |
|a Cytokines
|2 NLM
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| 650 |
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7 |
|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a Ligands
|2 NLM
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| 650 |
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7 |
|a Lipopolysaccharides
|2 NLM
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| 650 |
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7 |
|a Myelin-Oligodendrocyte Glycoprotein
|2 NLM
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| 650 |
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7 |
|a Peptide Fragments
|2 NLM
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| 650 |
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7 |
|a Toll-Like Receptors
|2 NLM
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| 650 |
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7 |
|a myelin oligodendrocyte glycoprotein (35-55)
|2 NLM
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| 650 |
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7 |
|a Guanosine
|2 NLM
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| 650 |
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7 |
|a 12133JR80S
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 650 |
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7 |
|a loxoribine
|2 NLM
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| 650 |
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7 |
|a 9CAS0V66OI
|2 NLM
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| 700 |
1 |
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|a Weber, Andreas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mausberg, Anne K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Heininger, Maximilian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Opdenhövel, Felicitas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kieseier, Bernd C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hartung, Hans P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hofstetter, Harald H
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 170(2016) vom: 01. Sept., Seite 22-30
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:170
|g year:2016
|g day:01
|g month:09
|g pages:22-30
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2016.05.008
|3 Volltext
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|a GBV_ILN_11
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|a GBV_ILN_24
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 170
|j 2016
|b 01
|c 09
|h 22-30
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