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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1155/2016/2123748
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|a eng
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| 100 |
1 |
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|a Jang, Sung-Soo
|e verfasserin
|4 aut
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| 245 |
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|a Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity
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|c 2016
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|a Text
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|a ƒaComputermedien
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|a Date Completed 30.12.2016
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline. Pathologic accumulation of soluble amyloid-β (Aβ) oligomers impairs synaptic plasticity and causes epileptic seizures, both of which contribute to cognitive dysfunction in AD. However, whether seizures could regulate Aβ-induced synaptic weakening remains unclear. Here we show that a single episode of electroconvulsive seizures (ECS) increased protein expression of membrane-associated STriatal-Enriched protein tyrosine Phosphatase (STEP61) and decreased tyrosine-phosphorylation of its substrates N-methyl D-aspartate receptor (NMDAR) subunit GluN2B and extracellular signal regulated kinase 1/2 (ERK1/2) in the rat hippocampus at 2 days following a single ECS. Interestingly, a significant decrease in ERK1/2 expression and an increase in APP and Aβ levels were observed at 3-4 days following a single ECS when STEP61 level returned to the baseline. Given that pathologic levels of Aβ increase STEP61 activity and STEP61-mediated dephosphorylation of GluN2B and ERK1/2 leads to NMDAR internalization and ERK1/2 inactivation, we propose that upregulation of STEP61 and downregulation of GluN2B and ERK1/2 phosphorylation mediate compensatory weakening of synaptic strength in response to acute enhancement of hippocampal network activity, whereas delayed decrease in ERK1/2 expression and increase in APP and Aβ expression may contribute to the maintenance of this synaptic weakening
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|a Journal Article
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|a Amyloid beta-Peptides
|2 NLM
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|a NR2B NMDA receptor
|2 NLM
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|a Receptors, N-Methyl-D-Aspartate
|2 NLM
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|a Protein Tyrosine Phosphatases
|2 NLM
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| 650 |
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|a EC 3.1.3.48
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| 700 |
1 |
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|a Royston, Sara E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Gunhee
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Shuwei
|e verfasserin
|4 aut
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| 700 |
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|a Chung, Hee Jung
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2016(2016) vom: 14., Seite 2123748
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnns
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|g volume:2016
|g year:2016
|g day:14
|g pages:2123748
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|u http://dx.doi.org/10.1155/2016/2123748
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