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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201505025
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|a eng
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|a Versluis, Frank
|e verfasserin
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|a Synthetic Self-Assembled Materials in Biological Environments
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|c 2016
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|a Text
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|a Date Completed 09.10.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Synthetic self-assembly has long been recognized as an excellent approach for the formation of ordered structures on the nanoscale. Although the development of synthetic self-assembling materials has often been inspired by principles observed in nature (e.g., the assembly of lipids, DNA, proteins), until recently the self-assembly of synthetic molecules has mainly been investigated ex vivo. The past few years however, have witnessed the emergence of a research field in which synthetic, self-assembling systems are used that are capable of operating as bioactive materials in biological environments. Here, this up-and-coming field, which has the potential of becoming a key area in chemical biology and medicine, is reviewed. Two main categories of applications of self-assembly in biological environments are identified and discussed, namely therapeutic and imaging agents. Within these categories key concepts, such as triggers and molecular constraints for in vitro/in vivo self-assembly and the mode of interaction between the assemblies and the biological materials will be discussed
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|a Journal Article
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|a biomaterials
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|a cellular imaging
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|a enzymes
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|a self-assembly
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|a therapeutics
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|a Biological Products
|2 NLM
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| 650 |
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|a Enzymes
|2 NLM
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| 700 |
1 |
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|a van Esch, Jan H
|e verfasserin
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|a Eelkema, Rienk
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 28(2016), 23 vom: 04. Juni, Seite 4576-92
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|g volume:28
|g year:2016
|g number:23
|g day:04
|g month:06
|g pages:4576-92
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|u http://dx.doi.org/10.1002/adma.201505025
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