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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.03.009
|2 doi
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|a pubmed24n0861.xml
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|e rakwb
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|a eng
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| 100 |
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|a Fan, Tingting
|e verfasserin
|4 aut
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|a Treating psoriasis by targeting its susceptibility gene Rel
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 31.08.2016
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|a Date Revised 19.04.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a Psoriasis is a chronic inflammatory disorder of the skin. Accumulating evidence indicates that the Rel gene, a member of the NF-κB family, is a risk factor for the disease. We sought to investigate whether psoriasis can be prevented by directly targeting the Rel gene transcript, i.e., the c-Rel mRNA. Using chemically-modified c-Rel specific siRNA (siRel) and poly(ethylene glycol)-b-poly(l-lysine)-b-poly(l-leucine) (PEG-PLL-PLLeu) micelles, we successfully knocked down the expression of c-Rel, and showed that the expression of cytokine IL-23, a direct target of c-Rel that can drive the development of IL-17-producing T cells, was markedly inhibited. More importantly, treating mice with siRel not only prevented but also ameliorated imiquimod (IMQ)-induced psoriasis. Mechanistic studies showed that siRel treatment down-regulated the expression of multiple inflammatory cytokines. Taken together, these results indicate that the susceptibility gene Rel can be targeted to treat and prevent psoriasis
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a IL-17A
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|a PEG-PLL-PLLeu micelles
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|a Psoriasis
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|a c-Rel
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|a siRNA
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|a RNA, Small Interfering
|2 NLM
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|a RNA-Induced Silencing Complex
|2 NLM
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| 700 |
1 |
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|a Wang, Shaowen
|e verfasserin
|4 aut
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| 700 |
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|a Yu, Linjiang
|e verfasserin
|4 aut
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| 700 |
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|a Yi, Huqiang
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Ruiling
|e verfasserin
|4 aut
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| 700 |
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|a Geng, Wenwen
|e verfasserin
|4 aut
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| 700 |
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|a Wan, Xiaochun
|e verfasserin
|4 aut
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| 700 |
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|a Ma, Yifan
|e verfasserin
|4 aut
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| 700 |
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|a Cai, Lintao
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Youhai H
|e verfasserin
|4 aut
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| 700 |
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|a Ruan, Qingguo
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 165(2016) vom: 15. Apr., Seite 47-54
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|x 1521-7035
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|g volume:165
|g year:2016
|g day:15
|g month:04
|g pages:47-54
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|u http://dx.doi.org/10.1016/j.clim.2016.03.009
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