Treating psoriasis by targeting its susceptibility gene Rel

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 165(2016) vom: 15. Apr., Seite 47-54
1. Verfasser:	Fan, Tingting (VerfasserIn)
Weitere Verfasser:	Wang, Shaowen, Yu, Linjiang, Yi, Huqiang, Liu, Ruiling, Geng, Wenwen, Wan, Xiaochun, Ma, Yifan, Cai, Lintao, Chen, Youhai H, Ruan, Qingguo
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2016
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't IL-17A PEG-PLL-PLLeu micelles Psoriasis c-Rel siRNA RNA, Small Interfering RNA-Induced Silencing Complex

Beschreibung
Zusammenfassung:	Copyright © 2016 Elsevier Inc. All rights reserved. Psoriasis is a chronic inflammatory disorder of the skin. Accumulating evidence indicates that the Rel gene, a member of the NF-κB family, is a risk factor for the disease. We sought to investigate whether psoriasis can be prevented by directly targeting the Rel gene transcript, i.e., the c-Rel mRNA. Using chemically-modified c-Rel specific siRNA (siRel) and poly(ethylene glycol)-b-poly(l-lysine)-b-poly(l-leucine) (PEG-PLL-PLLeu) micelles, we successfully knocked down the expression of c-Rel, and showed that the expression of cytokine IL-23, a direct target of c-Rel that can drive the development of IL-17-producing T cells, was markedly inhibited. More importantly, treating mice with siRel not only prevented but also ameliorated imiquimod (IMQ)-induced psoriasis. Mechanistic studies showed that siRel treatment down-regulated the expression of multiple inflammatory cytokines. Taken together, these results indicate that the susceptibility gene Rel can be targeted to treat and prevent psoriasis
Beschreibung:	Date Completed 31.08.2016 Date Revised 19.04.2016 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2016.03.009