Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy

Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 28(2016), 10 vom: 09. März, Seite 1963-9
1. Verfasser: Wu, Meiying (VerfasserIn)
Weitere Verfasser: Meng, Qingshuo, Chen, Yu, Zhang, Lingxia, Li, Mengli, Cai, Xiaojun, Li, Yaping, Yu, Pengcheng, Zhang, Linlin, Shi, Jianlin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't cancer therapy gene delivery large pores multidrug resistance nanoparticles Alloys Antineoplastic Agents Drug Carriers mehr... Metals Oxides Silicon Dioxide 7631-86-9
Beschreibung
Zusammenfassung:© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
A stability-difference-selective bond-breakage strategy for the fabrication of largepore-sized hollow mesoporous organosilica nanoparticles (HMONs) is successfully developed. Moreover, surfacefunctionalized HMONs are successfully constructed to simultaneously deliver P-gp modulator siRNA and anticancer drug doxorubicin to reverse the multidrug resistance of cancer cells
Beschreibung:Date Completed 13.12.2016
Date Revised 18.03.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201505524