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231224s2016 xx |||||o 00| ||eng c |
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7 |
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|a 10.1002/adma.201503565
|2 doi
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|a pubmed24n0852.xml
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|a eng
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| 100 |
1 |
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|a Castleberry, Steven A
|e verfasserin
|4 aut
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| 245 |
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|a Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo
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|c 2016
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 13.12.2016
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a controlled local delivery
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|a diabetic wound healing
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|a layer-by-layer
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|a polymer coatings
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| 650 |
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|a siRNA delivery
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| 650 |
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|a RNA, Small Interfering
|2 NLM
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| 650 |
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|a Matrix Metalloproteinase 9
|2 NLM
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| 650 |
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|2 NLM
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| 700 |
1 |
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|a Almquist, Benjamin D
|e verfasserin
|4 aut
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1 |
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|a Li, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Reis, Tiago
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chow, John
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mayner, Sarah
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hammond, Paula T
|e verfasserin
|4 aut
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| 773 |
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|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 28(2016), 9 vom: 02. März, Seite 1809-17
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