Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo

Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 28(2016), 9 vom: 02. März, Seite 1809-17
1. Verfasser: Castleberry, Steven A (VerfasserIn)
Weitere Verfasser: Almquist, Benjamin D, Li, Wei, Reis, Tiago, Chow, John, Mayner, Sarah, Hammond, Paula T
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. controlled local delivery diabetic wound healing layer-by-layer polymer coatings siRNA delivery RNA, Small Interfering mehr... Matrix Metalloproteinase 9 EC 3.4.24.35
Beschreibung
Zusammenfassung:© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed
Beschreibung:Date Completed 13.12.2016
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201503565