|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM25562400X |
| 003 |
DE-627 |
| 005 |
20250219112652.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2016 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2015.12.001
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0852.xml
|
| 035 |
|
|
|a (DE-627)NLM25562400X
|
| 035 |
|
|
|a (NLM)26674280
|
| 035 |
|
|
|a (PII)S1521-6616(15)30070-X
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Wilhelm, Theresa R
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood
|b A semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses
|
| 264 |
|
1 |
|c 2016
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 28.06.2016
|
| 500 |
|
|
|a Date Revised 13.02.2016
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2015 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of systemic lupus erythematosus (SLE) as IFN-α producers and promoters of T-cell activation or tolerance. Here, we demonstrated by flow-cytometry and confocal microscopy that Siglec-1, a molecule involved in the regulation of adaptive immunoresponses, is expressed in a subset of semi-mature, myeloid-like pDCs in human blood. These pDCs express lower BDCA-2 and CD123 and higher HLA-DR and CD11c than Siglec-1-negative pDCs and do not produce IFN-α via TLR7/TLR9 engagement. In vitro, Siglec-1 expression was induced in Siglec-1-negative pDCs by influenza virus. Proportions of Siglec-1-positive/Siglec-1-negative pDCs were higher in SLE than in healthy controls and correlated with disease activity. Healthy donors immunized with yellow fever vaccine YFV-17D displayed different kinetics of the two pDC subsets during protective immune response. PDCs can be subdivided into two subsets according to Siglec-1 expression. These subsets may play specific roles in (auto)immune responses
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Erythematosus
|
| 650 |
|
4 |
|a Plasmacytoide dendritic cell
|
| 650 |
|
4 |
|a Siglec-1
|
| 650 |
|
4 |
|a Systemic lupus
|
| 650 |
|
7 |
|a Influenza Vaccines
|2 NLM
|
| 650 |
|
7 |
|a Interferon-alpha
|2 NLM
|
| 650 |
|
7 |
|a SIGLEC1 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Sialic Acid Binding Ig-like Lectin 1
|2 NLM
|
| 650 |
|
7 |
|a Toll-Like Receptor 9
|2 NLM
|
| 650 |
|
7 |
|a Yellow Fever Vaccine
|2 NLM
|
| 700 |
1 |
|
|a Taddeo, Adriano
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Winter, Oliver
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Schulz, Axel Ronald
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Mälzer, Julia-Nora
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Domingo, Cristina
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Biesen, Robert
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Alexander, Tobias
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Thiel, Andreas
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Radbruch, Andreas
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hiepe, Falk
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Gerl, Velia
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 163(2016) vom: 17. Feb., Seite 42-51
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:163
|g year:2016
|g day:17
|g month:02
|g pages:42-51
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2015.12.001
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 163
|j 2016
|b 17
|c 02
|h 42-51
|