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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.12.001
|2 doi
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|a pubmed24n0852.xml
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|a (NLM)26674280
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|a (PII)S1521-6616(15)30070-X
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wilhelm, Theresa R
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood
|b A semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses
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|c 2016
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 28.06.2016
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|a Date Revised 13.02.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of systemic lupus erythematosus (SLE) as IFN-α producers and promoters of T-cell activation or tolerance. Here, we demonstrated by flow-cytometry and confocal microscopy that Siglec-1, a molecule involved in the regulation of adaptive immunoresponses, is expressed in a subset of semi-mature, myeloid-like pDCs in human blood. These pDCs express lower BDCA-2 and CD123 and higher HLA-DR and CD11c than Siglec-1-negative pDCs and do not produce IFN-α via TLR7/TLR9 engagement. In vitro, Siglec-1 expression was induced in Siglec-1-negative pDCs by influenza virus. Proportions of Siglec-1-positive/Siglec-1-negative pDCs were higher in SLE than in healthy controls and correlated with disease activity. Healthy donors immunized with yellow fever vaccine YFV-17D displayed different kinetics of the two pDC subsets during protective immune response. PDCs can be subdivided into two subsets according to Siglec-1 expression. These subsets may play specific roles in (auto)immune responses
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Erythematosus
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| 650 |
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|a Plasmacytoide dendritic cell
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| 650 |
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|a Siglec-1
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| 650 |
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|a Systemic lupus
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| 650 |
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|a Influenza Vaccines
|2 NLM
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| 650 |
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|a Interferon-alpha
|2 NLM
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| 650 |
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7 |
|a SIGLEC1 protein, human
|2 NLM
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| 650 |
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7 |
|a Sialic Acid Binding Ig-like Lectin 1
|2 NLM
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| 650 |
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7 |
|a Toll-Like Receptor 9
|2 NLM
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| 650 |
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|a Yellow Fever Vaccine
|2 NLM
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| 700 |
1 |
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|a Taddeo, Adriano
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Winter, Oliver
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schulz, Axel Ronald
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mälzer, Julia-Nora
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Domingo, Cristina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Biesen, Robert
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Alexander, Tobias
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Thiel, Andreas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Radbruch, Andreas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hiepe, Falk
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gerl, Velia
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 163(2016) vom: 17. Feb., Seite 42-51
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:163
|g year:2016
|g day:17
|g month:02
|g pages:42-51
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2015.12.001
|3 Volltext
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|d 163
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|h 42-51
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