Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood A semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses

Siglec-1-positive plasmacytoid dendritic cells (pDCs) in human peripheral blood : A semi-mature and myeloid-like subset imbalanced during protective and autoimmune responses

Copyright © 2015 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 163(2016) vom: 17. Feb., Seite 42-51
1. Verfasser: Wilhelm, Theresa R (VerfasserIn)
Weitere Verfasser: Taddeo, Adriano, Winter, Oliver, Schulz, Axel Ronald, Mälzer, Julia-Nora, Domingo, Cristina, Biesen, Robert, Alexander, Tobias, Thiel, Andreas, Radbruch, Andreas, Hiepe, Falk, Gerl, Velia
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Erythematosus Plasmacytoide dendritic cell Siglec-1 Systemic lupus Influenza Vaccines Interferon-alpha SIGLEC1 protein, human Sialic Acid Binding Ig-like Lectin 1 mehr... Toll-Like Receptor 9 Yellow Fever Vaccine
Beschreibung
Zusammenfassung:Copyright © 2015 Elsevier Inc. All rights reserved.
Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of systemic lupus erythematosus (SLE) as IFN-α producers and promoters of T-cell activation or tolerance. Here, we demonstrated by flow-cytometry and confocal microscopy that Siglec-1, a molecule involved in the regulation of adaptive immunoresponses, is expressed in a subset of semi-mature, myeloid-like pDCs in human blood. These pDCs express lower BDCA-2 and CD123 and higher HLA-DR and CD11c than Siglec-1-negative pDCs and do not produce IFN-α via TLR7/TLR9 engagement. In vitro, Siglec-1 expression was induced in Siglec-1-negative pDCs by influenza virus. Proportions of Siglec-1-positive/Siglec-1-negative pDCs were higher in SLE than in healthy controls and correlated with disease activity. Healthy donors immunized with yellow fever vaccine YFV-17D displayed different kinetics of the two pDC subsets during protective immune response. PDCs can be subdivided into two subsets according to Siglec-1 expression. These subsets may play specific roles in (auto)immune responses
Beschreibung:Date Completed 28.06.2016
Date Revised 13.02.2016
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2015.12.001