|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM255519834 |
| 003 |
DE-627 |
| 005 |
20231224174651.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2016 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.201504288
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0851.xml
|
| 035 |
|
|
|a (DE-627)NLM255519834
|
| 035 |
|
|
|a (NLM)26663349
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Liu, Xin
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery
|
| 264 |
|
1 |
|c 2016
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 13.12.2016
|
| 500 |
|
|
|a Date Revised 30.09.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
|
| 520 |
|
|
|a A novel fusogenic lipidic polyplex (FLPP) vector is designed to fuse with cell membranes, mimicking viropexis, and eject the polyplex into the cytosol, where the cationic polymer is subsequently oxidized by intracellular reactive oxygen species and converts to being negatively charged, efficiently releasing the DNA. The vector delivering suicide gene achieves significantly better inhibition of tumor growth than doxorubicin
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a ROS-responsive
|
| 650 |
|
4 |
|a charge reversal polymers
|
| 650 |
|
4 |
|a fusogenic lipid vectors
|
| 650 |
|
4 |
|a gene delivery
|
| 650 |
|
4 |
|a phenylboronic acid (PBA)
|
| 650 |
|
7 |
|a Drug Carriers
|2 NLM
|
| 650 |
|
7 |
|a Polymers
|2 NLM
|
| 650 |
|
7 |
|a Reactive Oxygen Species
|2 NLM
|
| 650 |
|
7 |
|a DNA
|2 NLM
|
| 650 |
|
7 |
|a 9007-49-2
|2 NLM
|
| 700 |
1 |
|
|a Xiang, Jiajia
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhu, Dingcheng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Jiang, Liming
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhou, Zhuxian
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Tang, Jianbin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Xiangrui
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Huang, Yongzhuo
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Shen, Youqing
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 28(2016), 9 vom: 02. März, Seite 1743-52
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
|
| 773 |
1 |
8 |
|g volume:28
|g year:2016
|g number:9
|g day:02
|g month:03
|g pages:1743-52
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.201504288
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 28
|j 2016
|e 9
|b 02
|c 03
|h 1743-52
|