Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery

Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 28(2016), 9 vom: 02. März, Seite 1743-52
Auteur principal: Liu, Xin (Auteur)
Autres auteurs: Xiang, Jiajia, Zhu, Dingcheng, Jiang, Liming, Zhou, Zhuxian, Tang, Jianbin, Liu, Xiangrui, Huang, Yongzhuo, Shen, Youqing
Format: Article en ligne
Langue:English
Publié: 2016
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article Research Support, Non-U.S. Gov't ROS-responsive charge reversal polymers fusogenic lipid vectors gene delivery phenylboronic acid (PBA) Drug Carriers Polymers Reactive Oxygen Species plus... DNA 9007-49-2
Description
Résumé:© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
A novel fusogenic lipidic polyplex (FLPP) vector is designed to fuse with cell membranes, mimicking viropexis, and eject the polyplex into the cytosol, where the cationic polymer is subsequently oxidized by intracellular reactive oxygen species and converts to being negatively charged, efficiently releasing the DNA. The vector delivering suicide gene achieves significantly better inhibition of tumor growth than doxorubicin
Description:Date Completed 13.12.2016
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201504288