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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.5b03271
|2 doi
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|a pubmed24n0844.xml
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|a (DE-627)NLM25344800X
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|a (NLM)26442576
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Ramos, Adrian Paz
|e verfasserin
|4 aut
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| 245 |
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|a Chain Length of Free Fatty Acids Influences the Phase Behavior of Stratum Corneum Model Membranes
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 16.09.2016
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|a Date Revised 27.10.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The skin, the largest organ of the human body, forms a flexible interface between our internal and external environment that protects our organism from exogenous compounds as well as excessive water loss. The stratum corneum (SC), the outermost layer of mammal epidermis, is mainly responsible for the skin impermeability. The SC is formed by corneocytes embedded in a lipid matrix, which is mostly constituted of ceramides (Cer), free fatty acids (FFA), and cholesterol (Chol), organized in two coexisting crystalline lamellar phases. This arrangement of lipids is crucial to skin barrier function. The aim of this paper is to determine the impact of FFA chain length on the phase behavior of SC model lipid membranes using solid-state deuterium NMR and IR spectroscopy. We studied ternary mixtures of N-lignoceroyl-d-erythro-sphingosine (Cer24), cholesterol, and palmitic (FFA16) or lignoceric (FFA24) acid in an equimolar ratio. This proportion replicates the lipid composition found in the SC lipid matrix. Our studies revealed that the phase behavior of Cer24/FFA/Chol ternary mixtures is strongly affected by the length of the FFA. We found the formation of phase-separated crystalline lipid domains when using palmitic acid whereas the use of lignoceric acid results in a more homogeneous mixture. In addition, it was observed that mixtures with lignoceric acid form a gel phase, a very unusual feature for SC model mixtures
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Ceramides
|2 NLM
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|a Fatty Acids
|2 NLM
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|a Fatty Acids, Nonesterified
|2 NLM
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|a Membrane Lipids
|2 NLM
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|a Palmitic Acid
|2 NLM
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|a 2V16EO95H1
|2 NLM
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|a Cholesterol
|2 NLM
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|a 97C5T2UQ7J
|2 NLM
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| 650 |
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|a lignoceric acid
|2 NLM
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| 650 |
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|a RK3VCW5Y1L
|2 NLM
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| 700 |
1 |
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|a Lafleur, Michel
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 31(2015), 42 vom: 27. Okt., Seite 11621-9
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:31
|g year:2015
|g number:42
|g day:27
|g month:10
|g pages:11621-9
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|u http://dx.doi.org/10.1021/acs.langmuir.5b03271
|3 Volltext
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|d 31
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