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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201502003
|2 doi
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|a pubmed24n0840.xml
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|a (DE-627)NLM252142373
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|a (NLM)26305446
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Nguyen, Mary M
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 06.07.2016
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a MMPs
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|a enzyme-responsive
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|a intravenous injection
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|a myocardial infarction
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|a nanoparticles
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|a Drug Carriers
|2 NLM
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| 650 |
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|a Micelles
|2 NLM
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|a Polymers
|2 NLM
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| 650 |
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|a Matrix Metalloproteinase 2
|2 NLM
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| 650 |
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|a EC 3.4.24.24
|2 NLM
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| 650 |
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|a Mmp2 protein, rat
|2 NLM
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| 650 |
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|a EC 3.4.24.24
|2 NLM
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| 650 |
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|a Matrix Metalloproteinase 9
|2 NLM
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| 650 |
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|a EC 3.4.24.35
|2 NLM
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| 650 |
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|a Mmp9 protein, rat
|2 NLM
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| 650 |
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7 |
|a EC 3.4.24.35
|2 NLM
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| 700 |
1 |
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|a Carlini, Andrea S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chien, Miao-Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sonnenberg, Sonya
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Colin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Braden, Rebecca L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Osborn, Kent G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Yiwen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gianneschi, Nathan C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Christman, Karen L
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 27(2015), 37 vom: 07. Okt., Seite 5547-52
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:27
|g year:2015
|g number:37
|g day:07
|g month:10
|g pages:5547-52
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201502003
|3 Volltext
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