Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction

Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 27(2015), 37 vom: 07. Okt., Seite 5547-52
1. Verfasser: Nguyen, Mary M (VerfasserIn)
Weitere Verfasser: Carlini, Andrea S, Chien, Miao-Ping, Sonnenberg, Sonya, Luo, Colin, Braden, Rebecca L, Osborn, Kent G, Li, Yiwen, Gianneschi, Nathan C, Christman, Karen L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. MMPs enzyme-responsive intravenous injection myocardial infarction nanoparticles Drug Carriers Micelles mehr... Polymers Matrix Metalloproteinase 2 EC 3.4.24.24 Mmp2 protein, rat Matrix Metalloproteinase 9 EC 3.4.24.35 Mmp9 protein, rat
Beschreibung
Zusammenfassung:© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction
Beschreibung:Date Completed 06.07.2016
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201502003