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231224s2015 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1111/vcp.12284
|2 doi
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|a pubmed24n0840.xml
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|a (DE-627)NLM252003756
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|a (NLM)26291052
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Polak, Klaudia
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Dog erythrocyte antigen 1
|b mode of inheritance and initial characterization
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| 264 |
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1 |
|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 13.12.2016
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| 500 |
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a © 2015 American Society for Veterinary Clinical Pathology.
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|a BACKGROUND: The dog erythrocyte antigen (DEA) 1 blood group system remains poorly defined
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| 520 |
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|a OBJECTIVES: The purpose of the study was to determine the DEA 1 mode of inheritance and to characterize the DEA 1 antigen and alloantibodies
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| 520 |
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|a ANIMALS: Canine research colony families, clinic canine patients, and DEA 1.2+ blood bank dogs were studied
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| 520 |
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|a METHODS: Canine blood was typed by flow cytometry and immunochromatographic strips using anti-DEA 1 monoclonal antibodies. Gel column experiments with polyclonal and immunoblotting with monoclonal anti-DEA 1 antibodies were performed to analyze select samples. Cross-reactivity of human typing reagents against canine RBC and one monoclonal anti-DEA 1 antibody against human RBC panels was assessed
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| 520 |
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|a RESULTS: Typing of 12 families comprising 144 dogs indicated an autosomal dominant inheritance with ≥ 4 alleles: DEA 1- (0) and DEA 1+ weak (1+), intermediate (2+), and strong (3+ and 4+). Samples from 6 dogs previously typed as DEA 1.2+ were typed as DEA 1+ or DEA 1- using monoclonal antibodies. Human typing reagents produced varied reactions in tube agglutination experiments against DEA 1+ and DEA 1- RBC. Polypeptide bands were not detected on immunoblots using a monoclonal anti-DEA 1 antibody, therefore the anti-DEA 1 antibody may be specific for conformational epitopes lost during processing
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| 520 |
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|a CONCLUSIONS: The autosomal dominant inheritance of DEA 1 with ≥ 4 alleles indicates a complex blood group system; the antigenicity of each DEA 1+ type will need to be determined. The biochemical nature of the DEA 1 antigen(s) appears different from human blood group systems tested
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Blood groups
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| 650 |
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4 |
|a blood typing
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| 650 |
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4 |
|a canine
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| 650 |
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4 |
|a polymorphism
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| 650 |
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4 |
|a transfusion
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| 650 |
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|a Antibodies, Monoclonal
|2 NLM
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| 650 |
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7 |
|a Blood Group Antigens
|2 NLM
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| 650 |
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7 |
|a Isoantibodies
|2 NLM
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| 700 |
1 |
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|a Acierno, Michelle M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Raj, Karthik
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mizukami, Keijiro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Siegel, Don L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Giger, Urs
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 44(2015), 3 vom: 18. Sept., Seite 369-79
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
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| 773 |
1 |
8 |
|g volume:44
|g year:2015
|g number:3
|g day:18
|g month:09
|g pages:369-79
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| 856 |
4 |
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|u http://dx.doi.org/10.1111/vcp.12284
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 44
|j 2015
|e 3
|b 18
|c 09
|h 369-79
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