Hybrid Crosslinked Methylcellulose Hydrogel A Predictable and Tunable Platform for Local Drug Delivery

Hybrid Crosslinked Methylcellulose Hydrogel : A Predictable and Tunable Platform for Local Drug Delivery

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 27(2015), 34 vom: 09. Sept., Seite 5002-8
1. Verfasser: Pakulska, Malgosia M (VerfasserIn)
Weitere Verfasser: Vulic, Katarina, Tam, Roger Y, Shoichet, Molly S
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't design of experiment drug delivery hydrogels rheology spinal cord injuries Drug Carriers Hydrogels Polylactic Acid-Polyglycolic Acid Copolymer mehr... 1SIA8062RS Polyglycolic Acid 26009-03-0 Lactic Acid 33X04XA5AT Methylcellulose 9004-67-5
Beschreibung
Zusammenfassung:© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Design of experiment is used to develop a hybrid methylcellulose hydrogel that combines physical and chemical crosslinks, resulting in an injectable, in situ stiffening, and long-lasting material with predictable swelling and rheological properties. Chemical crosslinking is complete prior to injection, allowing for ease of use and storage. Controlled release of two relevant protein therapeutics and biocompatibility of the hydrogel are demonstrated
Beschreibung:Date Completed 06.06.2016
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201502767