Multifunctionality of Acidulated Serum Albumin on Inhibiting Zn²⁺-Mediated Amyloid β-Protein Fibrillogenesis and Cytotoxicity

Fibrillogenesis of amyloid β-proteins (Aβ) mediated by transition-metal ions such as Zn(2+) in neuronal cells plays a causative role in Alzheimer's disease. Hence, it is highly desired to design multifunctional agents capable of inhibiting Aβ aggregation and modulating metal-Aβ species. In this...

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Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 31(2015), 26 vom: 07. Juli, Seite 7374-80
1. Verfasser:	Xie, Baolong (VerfasserIn)
Weitere Verfasser:	Dong, Xiaoyan, Wang, Yongjian, Sun, Yan
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2015
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Amyloid beta-Peptides Peptide Fragments Serum Albumin amyloid beta-protein (1-42) Zinc J41CSQ7QDS