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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.4255
|2 doi
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|a pubmed24n0831.xml
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|a eng
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|a Naumczuk, Beata
|e verfasserin
|4 aut
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|a DOSY NMR and MALDI-TOF evidence of covalent binding the DNA duplex by trimethylammonium salts of topotecan upon near UV irradiation
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a Date Completed 12.04.2016
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|a Date Revised 23.07.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2015 John Wiley & Sons, Ltd.
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|a Using DOSY NMR and MALDI-TOF MS techniques, we present evidence that quaternary trimethylammonium salts of topotecan, [TPT-NMe3 ](+) X(-) (X = CF3SO3, HCOO), bind covalently the natural DNA oligomer upon near UV irradiation in water under physiological conditions. It is shown that formate salt is very reactive at pH 7 and requires short irradiation time. This weak irradiation at 365 nm paves the way for a new application of TPT derivatives in clinical use, which can dramatically increase the therapeutic effects of a medicine
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a DNA duplex
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|a MALDI-TOF MS
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|a NMR
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|a UV irradiation
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|a covalent binding
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|a topotecan
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|a Quaternary Ammonium Compounds
|2 NLM
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|a Salts
|2 NLM
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|a Topotecan
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|a Hyz, Karolina
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|4 aut
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|a Kawęcki, Robert
|e verfasserin
|4 aut
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|a Bocian, Wojciech
|e verfasserin
|4 aut
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|a Bednarek, Elżbieta
|e verfasserin
|4 aut
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|a Sitkowski, Jerzy
|e verfasserin
|4 aut
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|a Wielgus, Ewelina
|e verfasserin
|4 aut
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|a Kozerski, Lech
|e verfasserin
|4 aut
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 53(2015), 8 vom: 27. Aug., Seite 565-71
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|x 1097-458X
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|g volume:53
|g year:2015
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|g day:27
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|g pages:565-71
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