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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2015.04.008
|2 doi
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|a pubmed24n0828.xml
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|a (DE-627)NLM248624903
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|a (NLM)25934387
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|a (PII)S1521-6616(15)00138-2
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wang, Chen
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Involvement of high mobility group box 1 in the activation of C5a-primed neutrophils induced by ANCA
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|c 2015
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 24.08.2015
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2015 Elsevier Inc. All rights reserved.
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|a C5a plays a central role in antineutrophil cytoplasmic antibody (ANCA)-mediated neutrophil recruitment and activation. A previous study showed that C5a played a crucial role in the regulation of high mobility group box 1 (HMGB1) release from human neutrophils. The current study further investigated the interaction between C5a and HMGB1 in ANCA-induced neutrophil activation. The effects of HMGB1 inhibitors on the translocation of ANCA antigens, ANCA-induced respiratory burst and degranulation of C5a-primed neutrophils were tested. We found that blocking HMGB1 decreased C5a-mediated translocation of ANCA antigens, as well as ANCA-induced respiratory burst and degranulation of C5a-primed neutrophils. Further study showed that supernatant of C5a-primed neutrophils, which contained HMGB1, also caused translocation of ANCA antigens of primary neutrophils, whereas blocking HMGB1 decreased the translocation. In conclusion, blocking HMGB1 may attenuate ANCA-induced activation of C5a-primed neutrophils. The interaction between HMGB1 and C5a might play an important role in ANCA-induced neutrophil activation
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4 |
|a Journal Article
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|a Research Support, Non-U.S. Gov't
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4 |
|a ANCA
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| 650 |
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4 |
|a C5a
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| 650 |
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4 |
|a HMGB1
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| 650 |
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|a Neutrophils
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|a Antibodies, Antineutrophil Cytoplasmic
|2 NLM
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| 650 |
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|a HMGB1 Protein
|2 NLM
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| 650 |
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|a HMGB1 protein, human
|2 NLM
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| 650 |
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|a Complement C5a
|2 NLM
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| 650 |
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|a 80295-54-1
|2 NLM
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| 650 |
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|a Peroxidase
|2 NLM
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| 650 |
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|a EC 1.11.1.7
|2 NLM
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| 650 |
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|a Myeloblastin
|2 NLM
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| 650 |
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|a EC 3.4.21.76
|2 NLM
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| 700 |
1 |
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|a Wang, Huan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hao, Jian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Dong-Yuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Ming-Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Min
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 159(2015), 1 vom: 15. Juli, Seite 47-57
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:159
|g year:2015
|g number:1
|g day:15
|g month:07
|g pages:47-57
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2015.04.008
|3 Volltext
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