Cosolute effects on amyloid aggregation in a nondiffusion limited regime : intrinsic osmolyte properties and the volume exclusion principle
The effects of cosolutes on amyloid aggregation kinetics in vivo are critical and not fully understood. To explore the effects of cosolute additives, the in vitro behavior of destabilizing and stabilizing osmolytes with polymer cosolutes on the aggregation of a model amyloid, human insulin, is probe...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 31(2015), 14 vom: 14. Apr., Seite 4246-54
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| 1. Verfasser: |
Murray, Brian
(VerfasserIn) |
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| Weitere Verfasser: |
Rosenthal, Joseph,
Zheng, Zhongli,
Isaacson, David,
Zhu, Yingxi,
Belfort, Georges |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2015
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids
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| Schlagworte: | Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Amyloid
Insulin
Protein Aggregates
Guanidine
JU58VJ6Y3B |
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