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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1021/la5045865
|2 doi
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|a pubmed24n0822.xml
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|a (NLM)25730494
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Gasperini, Antonio A M
|e verfasserin
|4 aut
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| 245 |
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|a Association between cationic liposomes and low molecular weight hyaluronic acid
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 21.12.2015
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|a Date Revised 24.03.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a This work presents a study of the association between low molecular weight hyaluronic acid (16 kDa HA) and cationic liposomes composed of egg phosphatidylcholine (EPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). The cationic liposome/HA complexes were evaluated to determine their mesoscopic structure, average size, zeta potential, and morphology as a function of the amount of HA in the system. Small angle X-ray scattering results revealed that neighboring cationic liposomes either stick together after a partial coating of low concentration HA or disperse completely in excess of HA, but they never assemble as multilamellar vesicles. Cryo-transmission electron microscopy images confirm the existence of unilamellar vesicles and large aggregates of unilamellar vesicles for HA fractions up to 80% (w/w). High concentrations of HA (> 20% w/w) proved to be efficient for coating extruded liposomes, leading to particle complexes with sizes in the nanoscale range and a negative zeta potential
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Cations
|2 NLM
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|a Liposomes
|2 NLM
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|a Phosphatidylethanolamines
|2 NLM
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|a 1,2-dielaidoylphosphatidylethanolamine
|2 NLM
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|a 76391-83-8
|2 NLM
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|a Hyaluronic Acid
|2 NLM
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|a 9004-61-9
|2 NLM
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|a Puentes-Martinez, Ximena E
|e verfasserin
|4 aut
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|a Balbino, Tiago Albertini
|e verfasserin
|4 aut
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|a Rigoletto, Thais de Paula
|e verfasserin
|4 aut
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| 700 |
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|a Corrêa, Gabriela de Sá Cavalcanti
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cassago, Alexandre
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Portugal, Rodrigo Villares
|e verfasserin
|4 aut
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|a de La Torre, Lucimara Gaziola
|e verfasserin
|4 aut
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1 |
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|a Cavalcanti, Leide P
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 31(2015), 11 vom: 24. März, Seite 3308-17
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:31
|g year:2015
|g number:11
|g day:24
|g month:03
|g pages:3308-17
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|u http://dx.doi.org/10.1021/la5045865
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