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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201404788
|2 doi
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|a pubmed24n0816.xml
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|a eng
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1 |
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|a Sun, Jiashu
|e verfasserin
|4 aut
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|a Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake
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|c 2015
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|a Text
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|a ƒaComputermedien
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|a Date Completed 07.12.2015
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a biomedical applications
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|a cellular uptake
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|a core-shell nanoparticles
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|a drug delivery
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|a microfluidics
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|a Lipids
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|a Polylactic Acid-Polyglycolic Acid Copolymer
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|a Zhang, Lu
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|a Wang, Jiuling
|e verfasserin
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|a Feng, Qiang
|e verfasserin
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|a Liu, Dingbin
|e verfasserin
|4 aut
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|a Yin, Qifang
|e verfasserin
|4 aut
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|a Xu, Dongyan
|e verfasserin
|4 aut
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|a Wei, Yujie
|e verfasserin
|4 aut
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|a Ding, Baoquan
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|a Shi, Xinghua
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|a Jiang, Xingyu
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 27(2015), 8 vom: 25. Feb., Seite 1402-7
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