Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 27(2015), 8 vom: 25. Feb., Seite 1402-7
1. Verfasser: Sun, Jiashu (VerfasserIn)
Weitere Verfasser: Zhang, Lu, Wang, Jiuling, Feng, Qiang, Liu, Dingbin, Yin, Qifang, Xu, Dongyan, Wei, Yujie, Ding, Baoquan, Shi, Xinghua, Jiang, Xingyu
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't biomedical applications cellular uptake core-shell nanoparticles drug delivery microfluidics Lipids Polylactic Acid-Polyglycolic Acid Copolymer 1SIA8062RS mehr... Polyglycolic Acid 26009-03-0 Lactic Acid 33X04XA5AT
Beschreibung
Zusammenfassung:© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations
Beschreibung:Date Completed 07.12.2015
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201404788