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231224s2015 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.12.003
|2 doi
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|a pubmed24n0815.xml
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|a (PII)S1521-6616(14)00270-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Rahman, Sayma
|e verfasserin
|4 aut
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|a Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells
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|c 2015
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 30.04.2015
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|a Date Revised 07.12.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014. Published by Elsevier Inc.
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|a Control of human tuberculosis (TB) requires induction and maintenance of both macrophage and T cell effector functions. We demonstrate that pulmonary TB patients with a vitamin D deficiency had significantly reduced local levels of the vitamin D-inducible antimicrobial peptide LL-37 in granulomatous lesions compared to distal parenchyma from the infected lung. Instead, TB lesions were abundant in CD3(+) T cells and FoxP3(+) regulatory T cells as well as IgG-secreting CD20(+) B cells, particularly in sputum-smear positive patients with cavitary TB. Mycobacteria-specific serum IgG titers were also elevated in patients with active TB. An up-regulation of the B cell stimulatory cytokine IL-21 correlated with mRNA expression of CD20, total IgG and also IL-10 in the TB lesions. Altogether, vitamin D-deficient TB patients expressed a weak antimicrobial response but an IL-21 associated expansion of IgG-secreting B cells combined with a rise in FoxP3(+) regulatory T cells at the local site of infection
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antimicrobial peptide
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|a B cell
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|a Human
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|a Lung
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|a T cell
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|a Tuberculosis
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|a Antigens, CD20
|2 NLM
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|a Antimicrobial Cationic Peptides
|2 NLM
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|a FOXP3 protein, human
|2 NLM
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|a Forkhead Transcription Factors
|2 NLM
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| 650 |
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|a IL10 protein, human
|2 NLM
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| 650 |
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|a Immunoglobulin G
|2 NLM
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|a Interleukins
|2 NLM
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|a Interleukin-10
|2 NLM
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|a 130068-27-8
|2 NLM
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| 650 |
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|a 25-Hydroxyvitamin D 2
|2 NLM
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| 650 |
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|a 21343-40-8
|2 NLM
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| 650 |
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|a interleukin-21
|2 NLM
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| 650 |
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|a MKM3CA6LT1
|2 NLM
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|a Calcifediol
|2 NLM
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| 650 |
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|a Cathelicidins
|2 NLM
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| 700 |
1 |
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|a Rehn, Anders
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rahman, Jubayer
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Andersson, Jan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Svensson, Mattias
|e verfasserin
|4 aut
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| 700 |
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|a Brighenti, Susanna
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 156(2015), 2 vom: 02. Feb., Seite 85-97
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:156
|g year:2015
|g number:2
|g day:02
|g month:02
|g pages:85-97
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|u http://dx.doi.org/10.1016/j.clim.2014.12.003
|3 Volltext
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