Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells

Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells

Copyright © 2014. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 156(2015), 2 vom: 02. Feb., Seite 85-97
1. Verfasser: Rahman, Sayma (VerfasserIn)
Weitere Verfasser: Rehn, Anders, Rahman, Jubayer, Andersson, Jan, Svensson, Mattias, Brighenti, Susanna
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antimicrobial peptide B cell Human Lung T cell Tuberculosis Antigens, CD20 Antimicrobial Cationic Peptides mehr... FOXP3 protein, human Forkhead Transcription Factors IL10 protein, human Immunoglobulin G Interleukins Interleukin-10 130068-27-8 25-Hydroxyvitamin D 2 21343-40-8 interleukin-21 MKM3CA6LT1 Calcifediol P6YZ13C99Q Cathelicidins
Beschreibung
Zusammenfassung:Copyright © 2014. Published by Elsevier Inc.
Control of human tuberculosis (TB) requires induction and maintenance of both macrophage and T cell effector functions. We demonstrate that pulmonary TB patients with a vitamin D deficiency had significantly reduced local levels of the vitamin D-inducible antimicrobial peptide LL-37 in granulomatous lesions compared to distal parenchyma from the infected lung. Instead, TB lesions were abundant in CD3(+) T cells and FoxP3(+) regulatory T cells as well as IgG-secreting CD20(+) B cells, particularly in sputum-smear positive patients with cavitary TB. Mycobacteria-specific serum IgG titers were also elevated in patients with active TB. An up-regulation of the B cell stimulatory cytokine IL-21 correlated with mRNA expression of CD20, total IgG and also IL-10 in the TB lesions. Altogether, vitamin D-deficient TB patients expressed a weak antimicrobial response but an IL-21 associated expansion of IgG-secreting B cells combined with a rise in FoxP3(+) regulatory T cells at the local site of infection
Beschreibung:Date Completed 30.04.2015
Date Revised 07.12.2022
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2014.12.003