Large-pore ultrasmall mesoporous organosilica nanoparticles micelle/precursor co-templating assembly and nuclear-targeted gene delivery

Large-pore ultrasmall mesoporous organosilica nanoparticles : micelle/precursor co-templating assembly and nuclear-targeted gene delivery

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 27(2015), 2 vom: 14. Jan., Seite 215-22
1. Verfasser: Wu, Meiying (VerfasserIn)
Weitere Verfasser: Meng, Qingshuo, Chen, Yu, Du, Yanyan, Zhang, Lingxia, Li, Yaping, Zhang, Linlin, Shi, Jianlin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2015
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't gene delivery large mesopores mesoporous organosilicas nuclear-targeted Biocompatible Materials Gene Products, tat Micelles Silicon Dioxide 7631-86-9
Beschreibung
Zusammenfassung:© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP)
Beschreibung:Date Completed 03.09.2015
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201404256