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231224s2014 xx |||||o 00| ||eng c |
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Bakri, Sophie J
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Comparison of the tissue penetration and glide force of 22-gauge thin-wall needles for intravitreal implant administration
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| 264 |
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1 |
|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 27.10.2015
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|a Date Revised 05.01.2015
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|a published: Print
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|a Citation Status MEDLINE
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|a BACKGROUND AND OBJECTIVE: To identify a needle to improve intravitreal dexamethasone implant administration by evaluating ease of ocular tissue penetration and glide force, key characteristics of needle performance
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|a MATERIALS AND METHODS: Two custom-applicator needles coated with distinct lubricants (needles A and B) and the original dexamethasone implant needle were evaluated by five retina specialists. Ex vivo porcine eyes were injected, and a visual analog scale was used in ratings
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| 520 |
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|a RESULTS: Ease of ocular tissue penetration and glide force of needle B were rated significantly higher than that of the original applicator needle (P < .001), but there were no significant differences for needle A. Lot to lot, needle B was not significantly different in penetration and glide, whereas a significant difference was observed for penetration of needle A (P = .043)
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|a CONCLUSION: Needle design and lubricant appear to facilitate penetration and reduce glide force when administering dexamethasone intravitreal implants. Minimal lot-to-lot variation should be considered in needle choice
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4 |
|a Comparative Study
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Drug Implants
|2 NLM
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| 650 |
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7 |
|a Glucocorticoids
|2 NLM
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| 650 |
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7 |
|a Dexamethasone
|2 NLM
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| 650 |
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7 |
|a 7S5I7G3JQL
|2 NLM
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| 700 |
1 |
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|a Boyer, David S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Albini, Thomas A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Holekamp, Nancy M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ferrone, Philip J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bhagat, Rahul
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Novakovic, Zoran
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Ophthalmic surgery, lasers & imaging retina
|d 2013
|g 45(2014), 5 vom: 01. Sept., Seite 430-5
|w (DE-627)NLM224956647
|x 2325-8179
|7 nnns
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