Comparison of the tissue penetration and glide force of 22-gauge thin-wall needles for intravitreal implant administration
BACKGROUND AND OBJECTIVE: To identify a needle to improve intravitreal dexamethasone implant administration by evaluating ease of ocular tissue penetration and glide force, key characteristics of needle performance
| Veröffentlicht in: | Ophthalmic surgery, lasers & imaging retina. - 2013. - 45(2014), 5 vom: 01. Sept., Seite 430-5 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2014
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| Zugriff auf das übergeordnete Werk: | Ophthalmic surgery, lasers & imaging retina |
| Schlagworte: | Comparative Study Journal Article Research Support, Non-U.S. Gov't Drug Implants Glucocorticoids Dexamethasone 7S5I7G3JQL |
| Zusammenfassung: | BACKGROUND AND OBJECTIVE: To identify a needle to improve intravitreal dexamethasone implant administration by evaluating ease of ocular tissue penetration and glide force, key characteristics of needle performance MATERIALS AND METHODS: Two custom-applicator needles coated with distinct lubricants (needles A and B) and the original dexamethasone implant needle were evaluated by five retina specialists. Ex vivo porcine eyes were injected, and a visual analog scale was used in ratings RESULTS: Ease of ocular tissue penetration and glide force of needle B were rated significantly higher than that of the original applicator needle (P < .001), but there were no significant differences for needle A. Lot to lot, needle B was not significantly different in penetration and glide, whereas a significant difference was observed for penetration of needle A (P = .043) CONCLUSION: Needle design and lubricant appear to facilitate penetration and reduce glide force when administering dexamethasone intravitreal implants. Minimal lot-to-lot variation should be considered in needle choice |
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| Beschreibung: | Date Completed 27.10.2015 Date Revised 05.01.2015 published: Print Citation Status MEDLINE |
| ISSN: | 2325-8179 |