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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.08.008
|2 doi
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|a pubmed24n0804.xml
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|a (NLM)25173800
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|a (PII)S1521-6616(14)00199-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Sfikakis, P P
|e verfasserin
|4 aut
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|a Cadherin-11 mRNA transcripts are frequently found in rheumatoid arthritis peripheral blood and correlate with established polyarthritis
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 26.01.2015
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|a Date Revised 02.11.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a Rheumatoid arthritis (RA) synovial fibroblasts hyperexpress the mesenchymal cadherin-11, which is involved also in tumor invasion/metastasis, whereas anti-cadherin-11 therapeutics prevent and reduce experimental arthritis. To test the hypothesis that cadherin-11 is aberrantly expressed in RA peripheral blood, 100 patients (15 studied serially) and 70 healthy controls were analyzed by real-time reverse transcription-PCR. Cadherin-11 mRNA transcripts were detected in 69.2% of moderately/severely active RA, versus 31.8% of remaining patients (p=0.001), versus 17.1% of controls (p<0.0001). Notably, cadherin-11 positivity correlated significantly and independently only with established (>1year) polyarthritis (>4 swollen tender joints), by multivariate logistic regression analysis including various possible clinical/laboratory factors. Rare cells of undefined nature, detected by flow cytometry following CD45(-) enrichment, strongly expressed surface cadherin-11 (estimated 10-50cells/ml of blood) in 5/6 patients with polyarticular established disease versus 1/6 patients with early RA. Studies on the potential pathogenic role of circulating cells expressing cadherin-11 in RA are warranted
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|a Journal Article
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|a Biomarker
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|a Cadherin-11
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|a Peripheral blood
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|a Polyarthritis
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|a Rheumatoid arthritis
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|a Synovial fibroblast
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|a Cadherins
|2 NLM
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|a RNA, Messenger
|2 NLM
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|a osteoblast cadherin
|2 NLM
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|a 156621-71-5
|2 NLM
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| 700 |
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|a Christopoulos, P F
|e verfasserin
|4 aut
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| 700 |
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|a Vaiopoulos, A G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fragiadaki, K
|e verfasserin
|4 aut
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| 700 |
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|a Katsiari, C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kapsimali, V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lallas, G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Panayiotidis, P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Korkolopoulou, P
|e verfasserin
|4 aut
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| 700 |
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|a Koutsilieris, M
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 155(2014), 1 vom: 28. Nov., Seite 33-41
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:155
|g year:2014
|g number:1
|g day:28
|g month:11
|g pages:33-41
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|u http://dx.doi.org/10.1016/j.clim.2014.08.008
|3 Volltext
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