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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201402752
|2 doi
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|a eng
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1 |
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|a Pan, Limin
|e verfasserin
|4 aut
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| 245 |
1 |
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|a MSN-mediated sequential vascular-to-cell nuclear-targeted drug delivery for efficient tumor regression
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|c 2014
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|a Text
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|a ƒaComputermedien
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|a Date Completed 16.06.2015
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Mesoporous silica nanoparticles functionalized with peptides are developed for sequential drug delivery. The RGD peptide is used for vasculature/cell membrane targeting and the TAT peptide for nuclear targeting. Using this delivery strategy, a tumor in a murine xenograft model is successfully regressed
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|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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4 |
|a mesoporous materials
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4 |
|a nuclear targeting
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4 |
|a silica nanoparticles
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4 |
|a targeted drug delivery
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4 |
|a tumor regression
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|a Drug Carriers
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|a Gene Products, tat
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|a Oligopeptides
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|a He, Qianjun
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|a Shi, Jianlin
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|t Advanced materials (Deerfield Beach, Fla.)
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|g 26(2014), 39 vom: 22. Okt., Seite 6742-8
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