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20250217093025.0 |
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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.08.003
|2 doi
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|a pubmed25n0803.xml
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|a (DE-627)NLM24103115X
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|a (NLM)25128897
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|a (PII)S1521-6616(14)00194-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Landry, Nathalie
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens
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|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 04.11.2014
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a Cell-mediated immunity plays a major role in long-lived, cross-reactive protection against influenza virus. We measured long-term poly-functional and cross-reactive T cell responses to influenza hemagglutinin (HA) elicited by a new plant-made Virus-Like Particle (VLP) vaccine targeting either H1N1 A/California/7/09 (H1) or H5N1 A/Indonesia/5/05 (H5). In two independent clinical trials, we characterized the CD4(+) and CD8(+) T cell homotypic and heterotypic responses 6 months after different vaccination regimens. Responses of VLP-vaccinated subjects were compared with placebo and/or a commercial trivalent inactivated vaccine (TIV:Fluzone™) recipients. Both H1 and H5 VLP vaccines elicited significantly greater poly-functional CD4(+) T cell responses than placebo and TIV. Poly-functional CD8(+) T cell responses were also observed after H1 VLP vaccination. Our results show that plant-made HA VLP vaccines elicit both strong antibody responses and poly-functional, cross-reactive memory T cells that persist for at least 6 months after vaccination
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Randomized Controlled Trial
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| 650 |
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4 |
|a Cell-mediated immunity
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| 650 |
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|a Influenza
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| 650 |
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|a Long-term memory response
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| 650 |
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|a Nicotiana benthamiana
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| 650 |
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|a Vaccine
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| 650 |
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|a Virus-like particle
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| 650 |
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7 |
|a Antigens, Viral
|2 NLM
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| 650 |
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7 |
|a Biomarkers
|2 NLM
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| 650 |
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7 |
|a Influenza Vaccines
|2 NLM
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| 650 |
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7 |
|a Vaccines, Virus-Like Particle
|2 NLM
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| 700 |
1 |
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|a Pillet, Stéphane
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Favre, David
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Poulin, Jean-François
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Trépanier, Sonia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yassine-Diab, Bader
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ward, Brian J
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 154(2014), 2 vom: 15. Okt., Seite 164-77
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
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|g volume:154
|g year:2014
|g number:2
|g day:15
|g month:10
|g pages:164-77
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2014.08.003
|3 Volltext
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 154
|j 2014
|e 2
|b 15
|c 10
|h 164-77
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