Biodegradable ethylene-bis(propyl)disulfide-based periodic mesoporous organosilica nanorods and nanospheres for efficient in-vitro drug delivery

Biodegradable ethylene-bis(propyl)disulfide-based periodic mesoporous organosilica nanorods and nanospheres for efficient in-vitro drug delivery

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 26(2014), 35 vom: 17. Sept., Seite 6174-80
1. Verfasser: Croissant, Jonas (VerfasserIn)
Weitere Verfasser: Cattoën, Xavier, Man, Michel Wong Chi, Gallud, Audrey, Raehm, Laurence, Trens, Philippe, Maynadier, Marie, Durand, Jean-Olivier
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't biodegradable cancer disulfide drug delivery nanoparticles periodic mesoporous organosilica Antibiotics, Antineoplastic Disulfides mehr... Drug Carriers Ethylenes Silicon Dioxide 7631-86-9 Doxorubicin 80168379AG ethylene 91GW059KN7
Beschreibung
Zusammenfassung:© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells
Beschreibung:Date Completed 08.06.2015
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201401931