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231224s2014 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1080/08997659.2013.860059
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0796.xml
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|a (NLM)24895858
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Hu, Kun
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Relationship between permeability glycoprotein (P-gp) gene expression and enrofloxacin metabolism in Nile Tilapia
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| 264 |
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1 |
|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 04.09.2014
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| 500 |
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|a Date Revised 30.09.2020
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a The aim of this study was to analyze the influence of permeability glycoprotein (P-gp) gene expression on enrofloxacin (ENR) metabolism in aquatic animals. Nile Tilapia Oreochomis niloticus were fed different doses of ENR ranging from 0 to 80 mg/kg. The P-gp gene expression levels were determined by quantitative real-time PCR (qRT-PCR) at indicated time points after drug administration. Drug metabolism was determined by HPLC. The P-gp gene expression in liver and kidney was greatly enhanced 30 min after ENR administration at 40 mg/kg, peaked 3 h after drug administration, and then gradually decreased. Thirty minutes after a single oral administration of ENR (0, 20, 40, or 80 mg/kg), the P-gp gene expression increased in a dose-dependent manner. The P-gp gene expression levels in the kidney were significantly higher than those in the liver. Additionally, the metabolic rate of ENR in kidney was more rapid than that in liver. Furthermore, a close correlation was found between P-gp gene expression and ENR concentrations. These results suggest that P-gp may be involved in the ENR metabolism process in Nile Tilapia, providing a novel model for the potential utility of gene expression and drug metabolism studies in aquatic animals
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a ATP Binding Cassette Transporter, Subfamily B, Member 1
|2 NLM
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| 650 |
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7 |
|a Anti-Bacterial Agents
|2 NLM
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| 650 |
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7 |
|a Fluoroquinolones
|2 NLM
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| 650 |
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7 |
|a Enrofloxacin
|2 NLM
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| 650 |
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7 |
|a 3DX3XEK1BN
|2 NLM
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| 700 |
1 |
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|a Cheng, Gang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Haixin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Huicong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ruan, Jiming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fang, Wenhong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Xianle
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Journal of aquatic animal health
|d 1998
|g 26(2014), 2 vom: 28. Juni, Seite 59-65
|w (DE-627)NLM098202006
|x 1548-8667
|7 nnns
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| 773 |
1 |
8 |
|g volume:26
|g year:2014
|g number:2
|g day:28
|g month:06
|g pages:59-65
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|u http://dx.doi.org/10.1080/08997659.2013.860059
|3 Volltext
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