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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.04.018
|2 doi
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|a pubmed24n0793.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Slone, Emily Archer
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Membrane lipid interactions in intestinal ischemia/reperfusion-induced Injury
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| 264 |
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|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 12.09.2014
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a Ischemia, lack of blood flow, and reperfusion, return of blood flow, are a common phenomenon affecting millions of Americans each year. Roughly 30,000 Americans per year experience intestinal ischemia-reperfusion (IR), which is associated with a high mortality rate. Previous studies of the intestine established a role for neutrophils, eicosanoids, the complement system and naturally occurring antibodies in IR-induced pathology. Furthermore, data indicate involvement of a lipid or lipid-like moiety in mediating IR-induced damage. It has been proposed that antibodies recognize exposure of neo-antigens, triggering action of the complement cascade. While it is evident that the pathophysiology of IR-induced injury is complex and multi-factorial, we focus this review on the involvement of eicosanoids, phospholipids and neo-antigens in the early pathogenesis. Lipid changes occurring in response to IR, neo-antigens exposed and the role of a phospholipid transporter, phospholipid scramblase 1 will be discussed
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a Ischemia;
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4 |
|a Lipids;
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|a Neo-antigen
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| 650 |
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4 |
|a Reperfusion;
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| 650 |
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|a Antibodies
|2 NLM
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| 650 |
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|a Antigens
|2 NLM
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|a Membrane Lipids
|2 NLM
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| 650 |
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|a Phospholipid Transfer Proteins
|2 NLM
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| 700 |
1 |
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|a Fleming, Sherry D
|e verfasserin
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|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 153(2014), 1 vom: 01. Juli, Seite 228-40
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|g volume:153
|g year:2014
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|g day:01
|g month:07
|g pages:228-40
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